Mazen Kheirbek, PhD

Associate Professor
M_Psychiatry
+1 415 514-8326
Publications: 

New myelin for old memories.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Kern MC, Kheirbek MA

Circuit and molecular architecture of a ventral hippocampal network.

Nature neuroscience

Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA

Circuit-Based Biomarkers for Mood and Anxiety Disorders.

Trends in neurosciences

Xia F, Kheirbek MA

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons.

Nature communications

Jimenez JC, Berry JE, Lim SC, Ong SK, Kheirbek MA, Hen R

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Cell

Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV

A Distributed Neural Code in the Dentate Gyrus and in CA1.

Neuron

Stefanini F, Kushnir L, Jimenez JC, Jennings JH, Woods NI, Stuber GD, Kheirbek MA, Hen R, Fusi S

A neuronal signature for monogamous reunion.

Proceedings of the National Academy of Sciences of the United States of America

Scribner JL, Vance EA, Protter DSW, Sheeran WM, Saslow E, Cameron RT, Klein EM, Jimenez JC, Kheirbek MA, Donaldson ZR

The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.

Neuron

Woods NI, Stefanini F, Apodaca-Montano DL, Tan IMC, Biane JS, Kheirbek MA

Preservation of a remote fear memory requires new myelin formation.

Nature neuroscience

Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA

Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.

eLife

Zhou P, Resendez SL, Rodriguez-Romaguera J, Jimenez JC, Neufeld SQ, Giovannucci A, Friedrich J, Pnevmatikakis EA, Stuber GD, Hen R, Kheirbek MA, Sabatini BL, Kass RE, Paninski L

Anxiety Cells in a Hippocampal-Hypothalamic Circuit.

Neuron

Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK, Wright MA, Zweifel L, Paninski L, Hen R, Kheirbek MA

Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens.

Neuroscience research

Tritschler L, Kheirbek MA, Dantec YL, Mendez-David I, Guilloux JP, Faye C, Doan J, Pham TH, Hen R, David DJ, Gardier AM

The Small World of a Fear Memory.

Neuron

Woods NI, Kheirbek MA

Imaging Adult Hippocampal Neurogenesis In Vivo.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Biane JS, Kheirbek MA

Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Carvalho Poyraz F, Holzner E, Bailey MR, Meszaros J, Kenney L, Kheirbek MA, Balsam PD, Kellendonk C

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding.

Neuron

Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek MA

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.

Hippocampus

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.

Neuron

Borgkvist A, Avegno EM, Wong MY, Kheirbek MA, Sonders MS, Hen R, Sulzer D

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Cell

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC

Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.

Neuron

Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R

Add neurons, subtract anxiety.

Scientific American

Kheirbek MA, Hen R

Local and regional heterogeneity underlying hippocampal modulation of cognition and mood.

Frontiers in behavioral neuroscience

Tannenholz L, Jimenez JC, Kheirbek MA

Dendritic inhibition in the hippocampus supports fear learning.

Science (New York, N.Y.)

Lovett-Barron M, Kaifosh P, Kheirbek MA, Danielson N, Zaremba JD, Reardon TR, Turi GF, Hen R, Zemelman BV, Losonczy A

Repeated cortico-striatal stimulation generates persistent OCD-like behavior.

Science (New York, N.Y.)

Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.

Neuron

Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.

Nature neuroscience

Kheirbek MA, Klemenhagen KC, Sahay A, Hen R

NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kheirbek MA, Tannenholz L, Hen R

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.

Nature

Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R

Dorsal vs ventral hippocampal neurogenesis: implications for cognition and mood.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Kheirbek MA, Hen R

Dopamine-dependent motor learning: insight into levodopa's long-duration response.

Annals of neurology

Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X

A molecular dissociation between cued and contextual appetitive learning.

Learning & memory (Cold Spring Harbor, N.Y.)

Kheirbek MA, Beeler JA, Chi W, Ishikawa Y, Zhuang X

Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X

A cAMP pathway underlying reward prediction in associative learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X

Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Beeler JA, Cao ZF, Kheirbek MA, Zhuang X

A molecular switch for induction of long-term depression of corticostriatal transmission.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kheirbek MA

Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hale ME, Kheirbek MA, Schriefer JE, Prince VE