Director, Clinical and Translational Sleep Research Program Director, Mood and Anxiety Spectrum Disorders and Interventional Psychiatry Programs Ray and Dagmar Dolby Distinguished Professor Vice Chair for Research in Psychiatry
Psychiatry
Dr. Krystal is the Ray and Dagmar Dolby Distinguished Professor in the Departments of Psychiatry and Neurology, Vice-Chair for Research in the Department of Psychiatry, Director of the Dolby Family Center for Mood Disorders, Director of the UCSF Interventional Psychiatry Program and Director of the Clinical and Translational Sleep Research Laboratory. His work focuses on the development of biomarkers for mood and sleep disorders and their application in developing novel, personalized treatments for these conditions.
Publications
Rapid homotopic communication between human orbitofrontal subregions.
Current biology : CB
Pharmacologic treatment data from chronic insomnia studies and the application to individuals with acute insomnia, a narrative review.
Sleep medicine reviews
Empirical limitations of current low-intensity focused ultrasound simulation platforms.
medRxiv : the preprint server for health sciences
Toward Individualized Deep Brain Stimulation: A Stereoelectroencephalography-Based Workflow for Neurostimulation Target Identification.
Neuromodulation : journal of the International Neuromodulation Society
The Effectiveness of Digital Cognitive Behavioral Therapy to Treat Insomnia Disorder in US Adults: Nationwide Decentralized Randomized Controlled Trial.
JMIR mental health
Towards individualized deep brain stimulation: A stereoencephalography-based workflow for unbiased neurostimulation target identification.
bioRxiv : the preprint server for biology
Integrating expert knowledge into large language models improves performance for psychiatric reasoning and diagnosis.
Psychiatry research
Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity.
Translational psychiatry
Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Simulated Reasoning and Self-Verification in Generalist Large Language Models for Psychiatric Diagnostic Performance: Cross-Sectional Study.
medRxiv : the preprint server for health sciences
Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial.
JAMA psychiatry
A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.
Journal of clinical psychopharmacology
Integrating Expert Knowledge into Large Language Models Improves Performance for Psychiatric Reasoning and Diagnosis.
medRxiv : the preprint server for health sciences
Stereo-encephalography-guided multi-lead deep brain stimulation for treatment-refractory obsessive compulsive disorder - study design and individualized surgical targeting approach.
medRxiv : the preprint server for health sciences
Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice.
The Journal of clinical psychiatry
Computationally-informed insights into anhedonia and treatment by k-opioid receptor antagonism.
Biological psychiatry. Cognitive neuroscience and neuroimaging
Assessing the Accuracy and Reliability of Large Language Models in Psychiatry Using Standardized Multiple-Choice Questions: Cross-Sectional Study.
Journal of medical Internet research
Selective KOR antagonist alters functional patch sizes in individualized brain system: results from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.
Journal of mood and anxiety disorders
Clinical Neurosciences Training for Psychiatry Residents: Implementing the Competency-Based Medical Education Framework.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Best practices for clinical trials of deep brain stimulation for neuropsychiatric indications.
Frontiers in human neuroscience
Rapid resolution of depression and epilepsy following resection of a septal region tumor: illustrative case.
Journal of neurosurgery. Case lessons
The effect of doxepin 3 mg on sleep latency: a pooled analysis of two phase 3 trials.
Sleep & breathing = Schlaf & Atmung
Invasive Brain Mapping Identifies Personalized Therapeutic Neuromodulation Targets for Obsessive-Compulsive Disorder.
medRxiv : the preprint server for health sciences
Effects of Recruitment Messaging on Ethnic/Racial Minority Screening in a RCT for Prenatal Insomnia: An Experimental Approach.
Behavioral sleep medicine
Reply to Moline et al. Comment on "Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia. J. Clin. Med. 2023, 12, 2493".
Journal of clinical medicine
Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry.
Brain, behavior, and immunity
Therapeutic DBS for OCD Suppresses the Default Mode Network.
Human brain mapping
Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms.
Neuropsychopharmacology reports
Insomnia and the effect of zolpidem-extended-release on the sleep items of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia, and suicidal ideation: Relationship to patient age.
Journal of psychopharmacology (Oxford, England)
Therapeutic DBS for OCD Suppresses the Default Mode Network.
bioRxiv : the preprint server for biology
A Plea for Nuance: Should People with a Family History of Bipolar Disorder Be Excluded from Clinical Trials of Psilocybin Therapy?
Psychedelic medicine (New Rochelle, N.Y.)
Hyperarousal features in the sleep architecture of individuals with and without insomnia.
Journal of sleep research
Feasibility and Acceptability of Mindfulness-based Stress Reduction and Prenatal Sleep Classes for Poor Prenatal Sleep Quality: Pilot Randomized Controlled Trial.
Behavioral sleep medicine
Stereoelectroencephalography Electrode Implantation for Inpatient Workup of Treatment-Resistant Depression.
Neurosurgery
Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Human Anterior Insular Cortex Encodes Multiple Electrophysiological Representations of Anxiety-Related Behaviors.
bioRxiv : the preprint server for biology
Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements.
Frontiers in human neuroscience
Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.
Brain stimulation
Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
JAMA network open
Cortical synchrony and information flow during transition from wakefulness to light non-rapid eye movement sleep.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Comparative short-term safety and efficacy of hypnotics: A quantitative risk-benefit analysis.
Journal of sleep research
Insomnia medications: History, characteristics, and guidelines for optimal use in clinical practice.
Journal of sleep research
The effect of zolpidem-CR on the suicide item of the Hamilton Rating Scale for Depression in outpatients with depression, insomnia and suicidal ideation: Lessons learned.
Psychiatry research
Association between Insomnia and Mental Health and Neurocognitive Outcomes Following Traumatic Brain Injury.
Journal of neurotrauma
Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study.
Journal of affective disorders
Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.
Journal of visualized experiments : JoVE
Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.
Brain stimulation
Closed-loop neurostimulation for the treatment of psychiatric disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Objective sleep duration and response to combined pharmacotherapy and cognitive behavioral insomnia therapy among patients with comorbid depression and insomnia: a report from the TRIAD study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Do Insomnia Treatments Improve Daytime Function?
Journal of clinical medicine
Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.
Journal of clinical medicine
International consensus statement on obstructive sleep apnea.
International forum of allergy & rhinology
Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia.
Journal of clinical medicine
Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care.
Journal of clinical medicine
What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder?
Journal of clinical medicine
Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence.
Journal of clinical medicine
Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.
Brain stimulation
Changes in intracranial neurophysiology associated with acute COVID-19 infection.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice.
The Journal of clinical psychiatry
Longitudinal study to assess antidepressant treatment patterns and outcomes in individuals with depression in the general population.
Journal of affective disorders
Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression.
Nature medicine
Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.
Journal of affective disorders
Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression.
Journal of psychiatric research
Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention.
Global advances in health and medicine
Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.
Nature and science of sleep
Links between the brain and body during sleep: implications for memory processing.
Trends in neurosciences
Trajectories of Insomnia in Adults After Traumatic Brain Injury.
JAMA network open
What Is Insomnia?
JAMA
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.
Molecular psychiatry
Correction to: Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.
Frontiers in human neuroscience
Diagnosing and Treating Insomnia in Adults and Older Adults.
The Journal of clinical psychiatry
Design of the national adaptive trial for PTSD-related insomnia (NAP study), VA cooperative study program (CSP) #2016.
Contemporary clinical trials
Optimizing Treatment for Insomnia.
The Journal of clinical psychiatry
Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder.
Suicide & life-threatening behavior
Association of Sleep and ß-Amyloid Pathology Among Older Cognitively Unimpaired Adults.
JAMA network open
Challenges in Managing Insomnia in Older People.
The Journal of clinical psychiatry
Evaluating lemborexant for the treatment of insomnia.
Expert opinion on pharmacotherapy
State-dependent responses to intracranial brain stimulation in a patient with depression.
Nature medicine
Correction to: Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.
Journal of patient-reported outcomes
Optimizing computation of overnight decline in delta power: Evidence for slower rate of decline in delta power in insomnia patients.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.
Journal of patient-reported outcomes
Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial.
JAMA psychiatry
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.
Current biology : CB
Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.
JMIR mHealth and uHealth
Blinding and bias in a hypnotic clinical trial.
Human psychopharmacology
Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.
Journal of affective disorders
An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Omitted Conflict of Interest Disclosures.
JAMA psychiatry
Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?
Sleep & breathing = Schlaf & Atmung
Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial.
JAMA psychiatry
A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating ?-opioid antagonism as a treatment for anhedonia.
Nature medicine
The assessment and management of insomnia: an update.
World psychiatry : official journal of the World Psychiatric Association (WPA)
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
The American journal of psychiatry
Genetics of the human circadian clock and sleep homeostat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.
The Journal of neuropsychiatry and clinical neurosciences
Sleep therapeutics and neuropsychiatric illness.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update.
Journal of psychopharmacology (Oxford, England)
Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.
Journal of psychiatric research
Sleep Pharmacogenetics: The Promise of Precision Medicine.
Sleep medicine clinics
Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.
Journal of Alzheimer's disease : JAD
The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.
Nature reviews. Drug discovery
Effect of ?-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.
International journal of clinical pharmacology and therapeutics
Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.
Anesthesia and analgesia
Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.
Journal of sleep research
Screening extremely obese pregnant women for obstructive sleep apnea.
American journal of obstetrics and gynecology
Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.
Sleep medicine
An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease.
Sleep medicine reviews
Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories.
Journal of consulting and clinical psychology
Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.
The Journal of clinical psychiatry
Dr McClintock and Colleagues Reply.
The Journal of clinical psychiatry
The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review.
Journal of affective disorders
Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation?
Anesthesiology
Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.
The international journal of neuropsychopharmacology
Adverse Effects of Hypnotic Medications.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.
Psychopharmacology
Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar.
American journal of human biology : the official journal of the Human Biology Council
Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi.
JAMA psychiatry
Sleep and Mood: Chicken or Egg?
Biological psychiatry
Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research.
Clinical psychology review
Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.
The Journal of clinical psychiatry
Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.
Depression and anxiety
Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.
Trends in pharmacological sciences
Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.
The American journal of psychiatry
Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.
The primary care companion for CNS disorders
Hibernation in a primate: does sleep occur?
Royal Society open science
Shining evolutionary light on human sleep and sleep disorders.
Evolution, medicine, and public health
Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.
Biological psychiatry
The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.
Human psychopharmacology
Recognizing and managing insomnia in primary care and specialty settings.
The Journal of clinical psychiatry
Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504.
The Journal of clinical psychiatry
New Developments in Insomnia Medications of Relevance to Mental Health Disorders.
The Psychiatric clinics of North America
Insomnia disorder.
Nature reviews. Disease primers
Current, emerging, and newly available insomnia medications.
The Journal of clinical psychiatry
Restricting Benzodiazepines to Short-Term Prescription.
JAMA psychiatry
Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression.
Brain stimulation
Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety.
Clinical trials (London, England)
Traumatic brain injury detection using electrophysiological methods.
Frontiers in human neuroscience
The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial.
Schizophrenia research
Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.
Biological psychiatry
Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.
Journal of affective disorders
Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy.
The journal of ECT
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.
The Lancet. Neurology
Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks.
Journal of psychopharmacology (Oxford, England)
Therapeutic approaches for shankopathies.
Developmental neurobiology
Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons.
Sleep medicine clinics
Obstructive sleep apnea and delirium: exploring possible mechanisms.
Sleep & breathing = Schlaf & Atmung
Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications.
Sleep medicine reviews
Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
The Journal of clinical psychiatry
Psychiatric disorders and sleep.
Neurologic clinics
Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder.
Psychiatry research
Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls.
International urogynecology journal
Shift work disorder case studies: applying management principles in clinical practice.
The Journal of clinical psychiatry
Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity.
The primary care companion for CNS disorders
Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.
Anesthesiology
How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder.
The Journal of clinical psychiatry
Insomnia is frequent in schizophrenia and associated with night eating and obesity.
Schizophrenia research
The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study.
Sleep
Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.
Biological psychiatry
Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis.
Archives of general psychiatry
Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients?
Journal of psychiatric research
Pharmacological advances in the treatment of insomnia.
Current pharmaceutical design
Antidepressant and Antipsychotic Drugs.
Sleep medicine clinics
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.
Journal of psychopharmacology (Oxford, England)
The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study.
The Journal of urology
Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia.
Sleep
A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression.
The Journal of clinical psychiatry
The treatment of primary insomnia.
CNS spectrums
The pharmacologic management of insomnia in patients with HIV.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice.
Sleep medicine reviews
Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep?
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II).
Journal of psychiatric research
Measuring sleep quality.
Sleep medicine
Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Effects of antipsychotic medications on sleep in schizophrenia.
International clinical psychopharmacology
Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder.
Archives of general psychiatry
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry
Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia.
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
Sleep quality varies as a function of 5-HTTLPR genotype and stress.
Psychosomatic medicine
Long-term issues in the treatment of sleep disorders.
CNS spectrums
Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
Psychosomatic medicine
Psychotic disorder in a patient with central and extrapontine myelinolysis.
Psychiatry and clinical neurosciences
The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder.
Biological psychiatry
Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Treating the health, quality of life, and functional impairments in insomnia.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder.
The Journal of clinical psychiatry
Sleep and psychiatric disorders: future directions.
The Psychiatric clinics of North America
Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
A polysomnography study of eszopiclone in elderly patients with insomnia.
Current medical research and opinion
Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder.
Biological psychiatry
Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial.
Archives of internal medicine
An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia.
Sleep medicine
A comparison of placebo and no-treatment during a hypnotic clinical trial.
International journal of clinical pharmacology and therapeutics
The effect of insomnia definitions, terminology, and classifications on clinical practice.
Journal of the American Geriatrics Society
Hypnotics should be considered for the initial treatment of chronic insomnia. Pro.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia.
The Journal of clinical psychiatry
Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine.
Psychopharmacology
Depression and insomnia in women.
Clinical cornerstone
Introduction: Definitions, measurements, and management in insomnia.
The Journal of clinical psychiatry
Panel discussion: changing how we think about insomnia.
The Journal of clinical psychiatry
The changing perspective on chronic insomnia management.
The Journal of clinical psychiatry
Subtyping primary insomnia: is sleep state misperception a distinct clinical entity?
Sleep medicine reviews
Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT.
The Journal of neuropsychiatry and clinical neurosciences
Insomnia in women.
Clinical cornerstone
NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.
Sleep
The use of valerian in neuropsychiatry.
CNS spectrums
Treatment of the modal patient: does one size fit nearly all?
The journal of ECT
Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices.
The journal of ECT
The development and retrospective testing of an electroencephalographic seizure quality-based stimulus dosing paradigm with ECT.
The journal of ECT
ECT stimulus intensity: are present ECT devices too limited?
The American journal of psychiatry
EEG effects of ECT: implications for rTMS.
Depression and anxiety
Stationarity and redundancy of multichannel EEG data recorded during generalized tonic-clonic seizures.
Brain topography
New methods of time series analysis of non-stationary EEG data: eigenstructure decompositions of time varying autoregressions.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Zolpidem for persistent insomnia in SSRI-treated depressed patients.
The Journal of clinical psychiatry
EEG correlates of the response to ECT: a possible antidepressant role of brain-derived neurotrophic factor.
The journal of ECT
Sleep in peri-menopausal and post-menopausal women.
Sleep medicine reviews
Low-dimensional chaos in bipolar disorder?
Archives of general psychiatry
Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings.
The Journal of neuropsychiatry and clinical neurosciences
The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.
Electroencephalography and clinical neurophysiology
Implementing a hospital-wide pain management strategy.
Canadian journal of nursing administration
Neuropsychiatric considerations in the use of electroconvulsive therapy.
The Journal of neuropsychiatry and clinical neurosciences
A comparison of EEG signal dynamics in waking, after anesthesia induction and during electroconvulsive therapy seizures.
Electroencephalography and clinical neurophysiology
Effect of ECT treatment number on the ictal EEG.
Psychiatry research
The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response.
Convulsive therapy
Cost effectiveness of maintenance ECT.
Convulsive therapy
ECT seizure duration: reliability of manual and computer-automated determinations.
Convulsive therapy
Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT.
Biological psychiatry
Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold.
Biological psychiatry
Ambulatory cassette polysomnography: findings from a large cohort of drug-free insomnia patients.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT.
The Journal of neuropsychiatry and clinical neurosciences
ECT seizure therapeutic adequacy.
Convulsive therapy
The present use of electroconvulsive therapy.
Annual review of medicine
The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.
Biological psychiatry
Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact.
Convulsive therapy
EEG evidence of more "intense" seizure activity with bilateral ECT.
Biological psychiatry
Ambulatory polysomnography: technical aspects and normative values.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
The electrophysiology of ECT: relevance to mechanism of action.
Clinical neuropharmacology
The monitoring and management of electrically induced seizures.
The Psychiatric clinics of North America
Shared features of neuroleptic malignant syndrome and alcohol abuse complications.
The Journal of clinical psychiatry
Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.
The Journal of neuropsychiatry and clinical neurosciences